TARDBP and neuroblastoma: However, in mouse neuroblastoma neuro-2a cells TDP-43 depletion inhibits neurite outgrowth (Iguchi et al., 2009), and in zebrafish embryos zTDP-43 depletion causes reduced axon length in motor neurons (Kabashi et al., 2010), suggesting that TDP-43 may have different roles during neuronal development in different neuronal populations and species.