Over the last few years, efforts to identify the genetic factors related to AMD have resulted in the identification in the nuclear genome of high-risk alleles in complement factor H (CFH) [6-8] and ARMS2 [9,10], and of susceptibility alleles in apolipoprotein E (ApoE), pigment epithelium-derived factor (PEDF), clusterin, Scavenger receptor class B member 1 (SRB1), hepatic lipase (LIPC), tissue inhibitor of metalloproteinases-3 (TIMP3), and VEGF [11-22]. The gene discussed is APOE; the disease is age-related macular degeneration.