First, because the expression of PAX3(+/−Q)-FOXO1 in ARMS tumors varies, the utilization of cell culture models having various levels of PAX3(+/−Q)-FOXO1 can provide an unbiased approach for identifying potential target genes of PAX3(+/−Q)-FOXO1. Here, FOXO1 is linked to alveolar rhabdomyosarcoma.