We previously reported a t(1;11) translocation in a single large Scottish family that showed genome-wide significant linkage for SZ, rMDD and jointly with BD.5 The t(1;11) translocation is balanced and structurally simple, but the outcome is genetically complex, disrupting the protein coding gene Disrupted in schizophrenia 1 (DISC1), the antisense non-coding gene Disrupted in schizophrenia 2 (DISC2) and the non-coding gene DISC1FP1, creating a DISC1/DISC1FP1 fusion transcript.6, 7, 8, 9, 10, 11. Here, DISC1 is linked to Behcet disease.