R37 is strictly conserved among orthologues and recent publications, including our own, have demonstrated biological effects of 37W on DISC1 interactions,32, 73 and shown a dominant-negative effect on the sub-cellular distribution of DISC1.44 Five additional family members of the 37W carrier were available for genotyping diagnosed with rMMD, generalised anxiety disorder, bipolar II or no psychiatric diagnosis at the time of assessment. This evidence concerns the gene DISC1 and generalized anxiety disorder.