HIF1A and neoplasm: TUNEL staining showed that apoptosis was prominently increased in the HIF-1α-miRNA group compared with the untreated and Scrambled groups (Fig. 8; P<0.01), Thus, these data show that silencing HIF-1α expression by miRNA significantly inhibits expression of HIF-1α mRNA and protein, and suppresses growth of human pulmonary adenocarcinoma in tumor-bearing nude mice.