Tumor weight in the HIF-1α-miRNA group was 1.14±0.08 g, significantly lower than that in the untreated (1.71±0.18 g) and the Scrambled group (1.75±0.26 g) (Fig. 6B, P<0.01), but differences between the untreated and Scrambled groups were not significant (P>0.05). The gene discussed is HIF1A; the disease is neoplasm.