ERBB2 and breast carcinoma: Secondly, LUX-breast 3 trial presented by Joensuu et al. is an ongoing phase II study, which randomizes HER2 positive breast cancer patients with progressive brain metastases (after trastuzumab or lapatinib based therapy) to single-agent afatinib versus afatinib + vinorelbine versus the investigator’s choice of approved therapy [46].