ERBB2 and neoplasm: Pre-clinical data with an HER2 amplified mouse model of brain metastasis using an orthotopic xenograft of BT474 cells in mice, has revealed that the combination of either trastuzumab and DC101 (anti-VEGFR2 inhibitor) or lapatinib and DC101 significantly slowed metastatic tumor growth in the brain with marked necrosis of brain lesions.