INS and Hypoglycemia: Hypoglycaemia can impact patient health-related quality of life (HRQoL) in two ways: firstly, through the direct physiological effects of repeated episodes; and secondly, through fear of future hypoglycaemia, leading to the adoption of avoidant, precautionary or compensatory actions (e.g., restricting holiday choices, avoiding physical exertion, defensive eating, insufficient insulin dosing) [7-10].