Thus, to determine their usefulness for regular diagnostic laboratory testing, we evaluated the serological profiles interpreted from the combined results of the Siemens Novagnost VCA IgM, VCA IgG, and EBNA-1 IgG assays, and the combined results of the Enzygnost Anti-EBV/IgG and Anti-EBV/IgM II microtiter assays to rule in, or rule out, acute EBV infection. Here, CD40LG is linked to Epstein-Barr virus infection.