In addition, genotoxic drugs such as etoposide trigger cellular senescence in normal and cancer cells via persistent activation of Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling and expression of IFN-stimulated genes including PML (Hubackova et al., 2010; Novakova et al., 2010). The gene discussed is SOAT1; the disease is cancer.