It becomes apparent that PML is regulated by different molecules in different cancer types, e.g., by E6AP in B-cell lymphoma (Wolyniec et al., 2012b), CK2, and PIAS1 in NSCL cancer (Scaglioni et al., 2006; Rabellino et al., 2012) whereas KLHL20/Pin1 in prostate adenocarcinoma (Yuan et al., 2011). Here, PIAS1 is linked to prostate adenocarcinoma.