As2O3 and ATRA have been extensively used in the clinic as anti-APL therapy and have the overlapping effect of targeting and inducing the degradation of the PML-RARα fusion protein, thereby overcoming the differentiation block and restoring the senescence program in APL cells (Chen et al., 1997; Shao et al., 1998; Ferbeyre, 2002) (Figure 3). Here, RARA is linked to acute promyelocytic leukemia.