While it is important to consider that the overall frequency of SDHA mutations in GIST is low given that SDH deficiency is seen in only ∼8% of all gastric GISTs (Miettinen et al., 2011), mutations in the SDHA subunit alone may be as common as mutations in all other subunits combined (Miettinen et al., 2012). The gene discussed is SDHA; the disease is gastrointestinal stromal tumor.