FasL+ microvesicles isolated from plasma of cancer patients have been linked to tumor progression, demonstrating that the presence of membrane-tethered FasL, and potentially of other molecules such as PDL-1 or TGF-β, could contribute to apoptosis of anti-tumor effector cells and thus to tumor escape (Whiteside, 2013). Here, TGFB1 is linked to neoplasm.