Subsequently, Fridman’s group has demonstrated by immunostaining of hundreds of CRC specimens that a strong local immune reaction, including CD3+, CD8+, and memory CD45RO+ T cells, correlates with a favorable prognosis regardless of the local extent of the tumor or the regional lymph node involvement (Pages et al., 2005; Fridman et al., 2011). The gene discussed is CD8A; the disease is neoplasm.