KLF15 and Ventricular arrhythmia: In a recent Nature paper by Jeyaraj et al. (2012) the Krüppel-like factor 15 (Klf15) was found to transcriptionally control rhythmic expression of KChIP2, a critical subunit required for generating Ito (Kuo et al., 2001), and that deficiency or excess of Klf15 increased susceptibility of ventricular arrhythmias.