Expression of PPAR in mouse colonic and small intestinal mucosa is extremely high (Mansen et al., 1996) and this may explain a body of work showing the role of PPAR in the modulation of experimental models of colitis (Katayama et al., 2003; Adachi et al., 2006; Dubuquoy et al., 2006; Celinski et al., 2011). Here, PPARA is linked to colitis.