SOD1 and amyotrophic lateral sclerosis: For example, the Cu/Zn superoxide dismutase type-1 (SOD-1) mouse model was developed in order to further understand the etiology and pathogenesis of a subtype of amyotrophic lateral sclerosis (Gurney et al., 1994; Wong et al., 1995; Raoul et al., 2005; Zhong et al., 2009; Towne et al., 2010; Riboldi et al., 2011).