The majority of AEs associated with the mTOR inhibitors are linked to the immunosuppressive action of this drug class, and include aphthous ulcers, fatigue, rash, mucositis, anorexia, gastrointestinal effects such as diarrhea and nausea, arthralgias, thrombocytopenia, and effects on lipid metabolism [74]. Here, MTOR is linked to mucositis.