In contrast, in a study following patients after major visceral surgery the presence of the Asp299Gly mutation did not correlate with the development of sepsis [33]; however the authors of this study also found in a mouse model of polymicrobial septic peritonitis a lack of TLR4 had no influence on systemic cytokine response nor the development of organ injury [33]. The gene discussed is TLR4; the disease is Sepsis.