Indeed several PCP components and/or modulators have been shown to promote metastasis in different human cancer types, such as WNT5A in melanoma, gastric cancer, and breast cancer by activating Rac and JNK [148-150], FZD7 in hepatocellular carcinoma and colon cancer, FZD10 in synovial sarcoma [151-154] or VANGL2, which promotes cellular migration and ECM invasion of fibrosarcoma tumour cells [12, 128, 155] (Fig. 2H). This evidence concerns the gene WNT5A and neoplasm.