TARDBP and amyotrophic lateral sclerosis: Moreover, we show that both loss and gain of Drosophila TDP-43 alter mRNA levels of the Drosophila homologues of glutamate transporters Excitatory amino acid transporter 1 (EAAT1) and EAAT2, thus linking glia and neuron pathology in TDP-43-related ALS and FTLD.