Moreover, and in addition to neuronal inclusions, glia-specific TDP-43 aggregates have been detected in ALS and FTLD pathology (8,25–27), and sarcoplasmic aggregates of TDP-43 have been found in ALS and FTLD cases that overlap with myopathies (26,28,29). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.