As both PI3K/AKT and telomerase appear to be potential targets for cancer therapy and radio-sensitization of brain cancers (5,11,15,16,43,45,55–57), we decided to study the links between telomerase activity and AKT pathway in human glioblastomas in order to challenge the idea of a ‘killing two birds with one stone’ radio-sensitizing strategy. This evidence concerns the gene AKT1 and brain cancer.