We previously demonstrated that cardiovascular depletion of PTEN resulted in pulmonary vascular remodeling consistent with pulmonary hypertension.34 In addition, Ravi, et al35–36 reported dysregulation of PTEN in monocrotaline‐ and hypoxia‐induced PH as well as in PH secondary to left heart failure supporting an important role for PTEN in SMCs on PH progression. Here, PTEN is linked to pulmonary arterial hypertension.