Although the mechanism by which adhesion molecule fucosylation affects drug resistance is not yet clear, it is currently believed that integrin-mediated tumor cell resistance is related to the following factors: (1) regulating apoptosis (Bax/BclX); (2) changing the drug targets (of Topo II); (3) inhibiting DNA injury, and enhancing DNA repair; (4) regulating P27 protein, etc. Our studies have shown that Lewis y-antigen is involved in the aforementioned process, and increases tumor cell drug resistance[15,17]. The gene discussed is BAX; the disease is neoplasm.