The following predictor variables were used in univariate analysis taking log BNP/log NT-proBNP as the dependent variables: age, gender, BMI, eGFR, ejection fraction, diabetes, hypertension, ischemic heart disease, cerebrovascular accident, dyslipidemia, anemia, smoking history, calcium channel blockers, beta-blockers, statins, digoxin, angiotensin converting enzyme inhibitor, angiotensin receptor blocker, diuretics and duration of kidney disease. The gene discussed is ACE; the disease is anemia (phenotype).