Our earlier study showed that effect of YGJD on liver fibrosis was associated with its ability to improve the activity of matrix metalloproteinase (MMP)-9 and contents of MMP-13, TIMP-2 and hepatocyte growth factor alpha (HGFalpha) and decrease the activity of MMP-2 and contents of α-SMA, TIMP-1, caspase-12 and hepatocyte apoptotic index [12]. Here, TIMP1 is linked to Hepatic fibrosis.