FXYD6 and colitis: In parallel, as a reflection of the mucosal functional impairment associated with colitis, we also observed about a 2–3 fold reduced expression of a set of genes reported to play major a role on water (aqp1-aquaporin 1 [31]), electrolytes (slc24a3-solute carrier family 24 member A3 being a Na+/K+/Ca2+ exchanger [32] or FXYD4 or FXYD6-FXYD domain containing ion transport regulator 4 or 6 [33]) or vitamin (slc5a6 – solute carrier family 5 member A6 being a Na+-dependent multivitamin transporter [34]) absorption.