Moreover, improvement or resolution of arthritis in murine models has been seen after treatment with antibodies to macrophage-derived angiogenic chemokines, including IL-8, ENA-78/CXCL5, MIP-1α/CCL3, MCP-1/CCL2, and fractalkine [35,96,97]. The gene discussed is CXCL5; the disease is arthritic joint disease.