AKT1 and urinary bladder cancer: Finally, we showed that in T24 bladder cancer cells apigenin upregulates Bax and Bad, activates caspase-3 and poly (ADPribose) polymerase (PARP), inhibits PI3K/Akt pathway, downregulates antiapoptotic protein Bcl-2 and Bcl-x, and leads to G2/M cell cycle arrest.