Notably, the Th2 cytokines IL-4, IL-5, IL-13 orchestrate these inflammatory processes: IL-4 is important for allergic sensitization and IgE production, eosinophil survival depends mainly on IL-5, whereas IL-13 has pleiotropic effects in the lungs, including a central role in the development of AHR and tissue remodeling [3]. Here, IL13 is linked to hypersensitivity reaction disease.