Differences between the mean ODs of IgA antibody against 3 out of 11 tested antigens in healthy controls versus patients with Crohn's disease were significant (P < 0.0035 for prodynorphin, P < 0.0044 for γ-gliadin-15, P < 0.0047 for TG (Table 2)). The gene discussed is PDYN; the disease is Crohn disease.