Based on these findings, we propose that for the early detection of immune activation in atypical or silent celiac disease and patients with IBD or Crohn's disease, IgG and IgA antibodies be measured not only against α-gliadin and TG, but also against water- and alcohol-soluble components of wheat, WGA, ω- and γ-gliadin, glutenin, gluteomorphin, and gliadin bound to TG. Here, CD79A is linked to Crohn disease.