Since earlier studies performed on intestinal T cells [5, 23–26] showed that response to various gliadin and other associated peptides is heterogeneous, we believe that the application of IgG and IgA antibodies against an array of antigens and peptides that includes α-,  γ-, and ω-gliadins, glutenin, WGA, gluteomorphin, prodynorphins, TG, and gliadin-bound TG can not only enhance the detection of celiac disease but may also assist in the early detection of atypical and silent celiac disease. The gene discussed is PDYN; the disease is celiac disease.