The factors significantly associated with active asthma at the follow-up end point were presence of initial atopic dermatitis (P < 0.001), sensitization to multiple aeroallergens (P < 0.001) and to multiple food allergens (P = 0.02), allergen polysensitization (P < 0.001), hypereosinophilia (P = 0.001), high total serum IgE (P = 0.002), and severe recurrent wheezing (P = 0.004). This evidence concerns the gene IGHE and atopic eczema.