Clonotypic IgM derived from CLL cells utilized unmutated (0%) VH3-11/DH3-10/JH5 gene segments with CDR3 = 57 nt (CARDLVLYYGSGSYYNWFDPW); clonotypic IgG derived from MM cells utilized mutated (8.3%) VH1-18/DH6-19/JH5 gene segments with CDR3 = 42 nt (CARDAGGGSRYWFDPW). Here, CD40LG is linked to B-cell chronic lymphocytic leukemia.