Furthermore, when examining 2 sample genes (SPINT2, DUSP6) shown by Elo et al to be up-regulated by IL-4 in T cells but, in our B cell experiments to be down-regulated by EBV infection, we again found that coincident IL-4 stimulation and EBV infection attenuated the effects of EBV infection (Figure 3B). This evidence concerns the gene SPINT2 and Epstein-Barr virus infection.