SPINT2 and neoplasm: It should be added that the importance of IL-4 response genes may not be confined to the ISGs that are induced by EBV; the smaller set of genes that are down-regulated by EBV but maintained or up-regulated by IL-4 includes two, SPINT2 [53], [54] and DUSP6 [55]–[57], that have been identified as candidate tumor-suppressor genes in non-hematopoietic cancers.