We have identified a strong association of GAB2 gene expression levels with neurofibrillary tangle and senile plaque counts in temporal cortex using only 102 subjects and shown that despite the fact that three of our four case-control series did not replicate the previously reported evidence that GAB2 variants protect against LOAD, our meta-analyses of 11,952-22,253 samples from this study and those published still showed a strong association at this locus. Here, GAB2 is linked to Neurofibrillary tangles.