GAB2 and Senile plaques: Taken together with our observation that GAB2 variants associated with decreased risk for LOAD may increase GAB2 mRNA levels (data taken from LCLs not the cortex), the correlation of increased GAB2 mRNA with decreased NFT and senile plaque counts in a tissue directly affected by LOAD provides further support for the hypothesis that Gab2 may protect neurons from LOAD pathology.