GAB2 and Alzheimer disease: Since the temporal cortex is more affected by AD pathology than the cerebellum it is reasonable to assume that due to regional specific cell death, the underlying distribution of cells would be different between the two areas, which could explain why we see less GAB2 expression in the cortex (mean ΔCT  = 1.0) versus the cerebellum (mean ΔCT  = 1.7) and why we see an association of GAB2 expression with AD pathology in the predominantly pathology-affected area only.