GRM2 and glioblastoma: Drugs that block the activation of these pathways, such as AMPA receptor by antagonist, NBQX, mGluR2/3 inhibitor, LY341495, EGFR inhibitor, Iressa, Akt activation inhibitors Wortmannin and LY294002 have been shown to reduce the growth of glioblastoma when used independently [9], [13], [17], [30].