This group and others also showed that miR-191 could selectively bind to MDM4-C allele mRNA but not MDM4-A allele mRNA, which resulting in a statistically significant increased expression of MDM4 mRNA and protein levels among MDM4 rs4245739 A allele carriers in ovarian cancer and retinoblastoma [20], [21]. Here, MDM4 is linked to retinoblastoma.