SERPINE1 and metabolic dysfunction-associated steatotic liver disease: IGFBP6 may be involved in liver fibrogenesis [50], [51] indicating elevated IGFBP6 in PAI-1 knockout hearts may play a role in cardiac-selective fibrogenesis; iii) Klf6, a 31 kDa zinc finger transcription factor, regulates TGF-β gene expression and is associated with fibrosis in non-alcoholic fatty liver diseases.