Biomarkers of end-organ disease noted elevated in HIV infection include the soluble vascular cell adhesion molecule-1 (sVCAM-1) and soluble intracellular adhesion molecule-1 (sICAM-1) as novel biomarkers of CVD [26], and the chemokine CXCL10, indicative of impaired cognitive function [27], [28]. The gene discussed is CXCL10; the disease is HIV infectious disease.