Previously, we have isolated a SPH protein (Sp-SPH) from hemocyte lysate supernatant (HLS) of a crustacean, the mud crab Scylla paramamosain, via a live bacterial-affinity matrix and determined the full-length cDNA sequence of Sp-SPH gene as well as its expression profile post bacterial infection [17]. This evidence concerns the gene TFF2 and bacterial infectious disease.