HLA-DQA1*0501, HLA-DQB1*0201 and HLA-DRB1*0301 alleles were also identified to be risk factors for pSS, whereas HLA-DQA1*0201, HLA-DQA1*0301 and HLA-DQB1*0501 were possible protective factors [34]. This evidence concerns the gene HLA-DQA1 and peeling skin syndrome.