It has also been reported that the polymorphism at the −308 of TNF-αgene could contribute to higher level of TNF-α [11].However, the associations between those polymorphisms, haplotypes and susceptibility to pSS remain unclear, the results about the role of IL-10 or TNF-αgene polymorphisms in pSS patients are inconsistent and inconclusive. This evidence concerns the gene TNF and peeling skin syndrome.