Treatment with a TNF neutralizing antibody, a locally active TNF inhibitor, antisense oligonucleotides and siRNA molecules specific for TNF were shown to be effective in the DSS-induced colitis model (Dharmani et al, 2011; Murthy et al, 2002; Myers et al, 2003; Ocampo et al, 2012). Here, TNF is linked to colitis.