To investigate whether MMP13 contributes to the lethal effects of sepsis, we compared the response of wild type (MMP13+/+) and MMP13-deficient (MMP13−/−) mice in the endotoxemia model, i.e., i.p. injection of LPS, a model of human sepsis (Cantaluppi et al, 2008; Cruz et al, ,). The gene discussed is MMP13; the disease is serum lipopolysaccharide activity.