Objectives: The aim of this work was to assess risk habits, clinical and cellular phenotypes and TP53 DNA changes in oral mucosa samples from patients with Oral Potentially Malignant Disorders (OPMD), in order to create models that enable genotypic and phenotypic patterns to be obtained that determine the risk of lesions becoming malignant.Study Design: Clinical phenotypes, family history of cancer and risk habits were collected in clinical histories. This evidence concerns the gene TP53 and cancer.