FGF21 and obesity due to melanocortin 4 receptor deficiency: Pre-clinical studies in animal models for obesity demonstrated that low doses of K-877 (0.3-3.0 mg/kg) had a greater TG-lowering efficacy than 1,000-fold higher doses (300 mg/kg) of fenofibrate, an effect that was accompanied by higher levels of plasma FGF-21[52].