PPARA and obesity due to melanocortin 4 receptor deficiency: Targets for PPARα include key genes involved in lipid metabolism, such as apo A-I, A-II and A-V, LPL and SR-BI, whereas PPARγ targets include genes involved in obesity and insulin resistance, such as ADIPOQ and ADRP. Consequently, PPARα primarily regulates lipid homeostasis[14], whereas PPARγ largely regulates adipogenesis and glucose homeostasis[33].