Among the wide spectrum of apoptosis regulatory proteins tested in our studies, the expression of proapoptotic proteins Bax, cleaved caspase-9, cleaved caspase-3, and cleaved PARP were found to be increased in RBM5-overexpressing tumor tissues, while the expression of apoptosis inhibitory protein Bcl-2 was observed at a lower level in RBM5-overexpressing tumor tissues. This evidence concerns the gene CASP9 and neoplasm.