In summary, we recently demonstrated that RBM5 overexpression can employ both TNF-α-mediated apoptotic pathways and mitochondrial apoptotic pathways to suppress the growth of lung adenocarcinoma, by establishing an implant tumor model in vivo, treated with attenuated Salmonella-RBM5, a plasmids delivery system. This evidence concerns the gene RBM5 and lung adenocarcinoma.