CD8A and brucellosis: This practice is inconsistent with the protective mechanisms against brucellosis since Alum is primarily associated with a Th2 response, FA elicits a mixed Th1/Th2 response and both have no demonstrated ability to stimulate of CD8+ T cell responses (Coffman et al., 2010); however, the use of Alum may be associated with its acceptance for use in human subjects.