Raf kinase inhibitor protein (RKIP) is a metastasis suppressor/immunosurveillance cancer gene, which acts as a negative regulator of both the MAPK cascade, initiated by Raf-1 (Yeung et al., 1999), and NF-κB activation, through the negative regulation of IκB (Yeung et al., 2001). This evidence concerns the gene RAF1 and cancer.