Importantly, OX40 mAb-mediated therapy is currently being tested in a Phase 1/2 trial for patients with metastatic melanoma (NCT01689870), as well as in a Phase 1 trial for patients with advanced forms of cancer (NCT01644968) although it has yet to be initiated for primary brain tumors, specifically. The gene discussed is TNFRSF4; the disease is brain neoplasm.