CXCR2 and chondrosarcoma: In addition to this direct link of MIF-CXCR2 signaling towards integrin activation, MIF has been shown to induce the migration of human chondrosarcoma cells by upregulating the transcription of the αvβ3 integrin through PI3K/AKT/NF-κB signaling in a CXCR2- and CXCR4-mediated way (Lee et al., 2012).