After 9 months storage of Patient 4 and 5 diabetic dementia protein-A eluates, a significantly more inhibitory form of EC activity appeared spontaneously (Table 3) having similar magnitude to the inhibitory activity recovered from the Patient 1 diabetic dementia and glaucoma protein-A eluate following brief exposure to the proprotein convertase (PC) furin (Table 3). This evidence concerns the gene FURIN and glaucoma.