GRIN1 and schizophrenia: Elimination of interneuronal expression of mature NMDARs post-natally, but prior to onset of adolescence, leads to a schizophrenia-like phenotype in mice (Belforte et al., 2010), suggesting that either the lower levels of the obligatory subunit (NR1) or higher levels of the NR3A subunit could interfere with the maturational changes in NMDARs and contribute to schizophrenia.