RELN and schizophrenia: Anomalous cortical development due to distorted distribution of neurons, especially in layer II of the entorhinal cortex from patients with schizophrenia has been reported (Jakob and Beckmann, 1986; Arnold et al., 1991, 1997; Falkai et al., 2000) at least in some cases, but not all (Jakob and Beckmann, 1986; Krimer et al., 1997; Bernstein et al., 1998), which could be consistent with more subtle alterations in reelin-mediated migration events than what is found in the reeler mouse.