The extent to which NMDAR subunit mRNAs are altered in the brains of people with schizophrenia varies with subunit and brain region, however, mRNA changes remain controversial, with decreases (Humphries et al., 1996; Sokolov, 1998; Law and Deakin, 2001; Beneyto and Meador-Woodruff, 2008; Weickert et al., 2012), increases (Akbarian et al., 1996; Dracheva et al., 2001; Schmitt et al., 2010) and no change (Akbarian et al., 1996) observed in NR1. The gene discussed is GRIN1; the disease is schizophrenia.