DNMT1 protein expression has been reported to increase progressively during the stages of pancreatic carcinogenesis and was found to be associated with tumor aggressiveness, suggesting that protein overexpression of DNMT1 and ensuing hypermethylation may be involved in multistage pancreatic carcinogenesis -- even though it may not translate into loss of mRNA expression [15]. The gene discussed is DNMT1; the disease is neoplasm.