NFKB1 and hepatocellular carcinoma: Recent studies have shown that IFN-α can accelerate TNF-induced tumor cell apoptosis by up-regulating Fas expression [20], while other studies have shown that pretreatment with IFN-α can inhibit the TRAIL-mediated NF-κB activation, thereby increasing the response of hepatoma cells to TRAIL-induced apoptotic signal [21].